Protein Modification Reagents
Medchemexpress LLC (S,R,S)-AHPC-PEG1-N3 | 2101200-09-1 | MFCD31807301 | 98.8% | 557.67 g/mol | C26H35N7O5S | 2 G
(S,R,S)-AHPC-PEG1-N3 is an azide-functionalized von Hippel-Lindau (VHL) ligand-linker conjugate used as a click chemistry reagent to attach VHL-binding modules to other molecules in PROTAC design and chemical biology studies. It contains a PEG1 spacer and a terminal azide for copper-catalyzed azide-alkyne cycloaddition, and is supplied as a solid with defined purity and molecular weight.
- Azide terminal for copper-catalyzed click chemistry.
- Peg1 spacer provides a short, flexible linker.
- VHL ligand enables E3 ligase recruitment in conjugates.
- High purity and characterized molecular weight for reproducible coupling.
- Solid, white to light yellow, with recommended cold storage for stability.
- Available in gram-scale pack sizes for synthesis and optimization workflows.
Cayman Chemical PomalIdomIde 4-PEG5-amInh 50mg
A PEGylated form of pomalidomide; has been conjugated to various ligands in the development of PROTACs
STA PHARMACEUTICAL US LLC Fmoc-N-PEG7-acid | 1 g | CAS 1863885-74-8 | MDL MFCD26142985
Fmoc-N-PEG7-acid is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 1 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1863885-74-8
- MDL: MFCD26142985
- InChIKey: QTWMNLIXRWCJSM-UHFFFAOYSA-N
- Molecular Weight: 619.708
- Molecular Formula: C32H45NO11
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25-octaoxa-4-azaoctacosan-28-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)O
Medchemexpress LLC Endo-BCN-PEG2-alcohol | 1807501-85-4 | 98.0% | C17H27NO5 | 10MG
endo-BCN-PEG2-alcohol is a PEG-based linker that combines a strained bicyclo[6.1.0]non-4-yne (BCN) reactive group with a terminal hydroxyl. It is intended for use in copper-free click chemistry, bioconjugation, and linker assembly in PROTAC synthesis.
- Contains BCN strained alkyne for copper-free click reactions.
- Terminal alcohol enables further functionalization.
- PEG2 spacer increases hydrophilicity and reduces steric hindrance.
- Suitable for PROTAC linker assembly and bioconjugation applications.
- Comes with analytical documentation and storage recommendations.
Medchemexpress LLC MPEG-PLA (PEG MW 3000 & PLA MW 50,000) | PEG MW 3000 & PLA MW 50,000 | 100 MG
MPEG-PLA (PEG MW 3000 & PLA MW 50,000) is a block copolymer used in laboratory chemical applications and for the manufacture of substances. It can be used to prepare nanoparticles for targeted drug delivery and is intended for research use only.
- Block copolymer structure
- Enables preparation of nanoparticles for targeted drug delivery
- For research use only
Medchemexpress LLC t-Boc-N-amido-PEG5-Tos | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 | C22H37NO9S | 250 MG
t-Boc-N-amido-PEG5-Tos is a Boc-protected PEG5 linker bearing a tosyl leaving group. The hydrophilic PEG spacer improves solubility of conjugates, the tosyl enables efficient nucleophilic substitution, and the Boc group can be removed under mild acidic conditions to expose a primary amine. The reagent is intended for synthetic chemistry and bioconjugation applications.
- Hydrophilic PEG5 spacer improves aqueous solubility.
- Tosyl leaving group facilitates nucleophilic substitution.
- Boc-protected amine allows orthogonal deprotection strategies.
- Suitable for linker construction, bioconjugation, and PROTAC synthesis.
- Available in small research quantities for laboratory use.
Medchemexpress LLC DBCO-PEG6-NHS ester | 96.0% | 737.79 | 5 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent that contains an NHS ester. This NHS ester specifically reacts with primary amines, such as the side chains of lysine residues or aminosilane-coated surfaces, forming covalent bonds efficiently under neutral or slightly alkaline conditions. Additionally, DBCO-PEG6-NHS ester includes a DBCO group, which can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Reacts specifically with primary amines.
- Contains a DBCO group for SPAAC with Azide groups.
eMolecules 2364591-79-5 | DBCO-PEG1-amine | Broadpharm391.471 | C23H25N3O3 | 98.000 | NCCOCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 462125391
DBCO-PEG1-amine | Broadpharm | 2364591-79-5391.471 | C23H25N3O3 | 98.000 | NCCOCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 462125391
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG6-CH2COOH | 10 g | CAS 437655-96-4 | MDL MFCD26142983
Fmoc-NH-PEG6-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-96-4
- MDL: MFCD26142983
- InChIKey: HANLHKUCDRJGKX-UHFFFAOYSA-N
- Molecular Weight: 561.628
- Molecular Formula: C29H39NO10
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azatetracosan-24-oic acid
- SMILES: O=C(NCCOCCOCCOCCOCCOCCOCC(O)=O)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2
Medchemexpress LLC DSPE-PEG-SH | 90.0% | 1,000 Da | C44H86NO10PS | 100 MG
DSPE-PEG-SH (MW 1000) is a thiol-terminated pegylated phospholipid composed of a DSPE lipid anchor linked to an approximately 1,000 Da polyethylene glycol chain ending in a free sulfhydryl. The amphiphilic molecule integrates into lipid bilayers and is used to functionalize liposomes and nanoparticles and to enable covalent conjugation to maleimide-activated ligands.
- Provides a thiol functional group for covalent conjugation.
- Anchors into lipid bilayers via the DSPE lipid tail.
- Enhances colloidal stability and circulation through PEGylation.
- Suitable for surface functionalization of liposomes and nanoparticles.
- Average molecular weight approximately 1,000 Da.
- Typical purity around 90%.
Medchemexpress LLC Dspe-peg-sh | 99.4% | 2000 (average) | (C2H4O)nC45H87N2O10PS | 25 MG
DSPE-PEG-SH is a thiolated pegylated phospholipid (average MW 2000) that provides a terminal -SH for covalent surface modification of lipid assemblies. Its amphipathic DSPE-PEG structure enables incorporation into liposomes and lipid nanoparticles for ligand attachment, stabilization, and targeted delivery via formation of stable thioether bonds with maleimide-functionalized molecules.
- Provides a terminal thiol for covalent conjugation.
- Incorporates into lipid bilayers for surface functionalization.
- Enables stable thioether linkage with maleimide reagents.
- Suitable for liposome and lipid nanoparticle formulations.
- Facilitates targeted delivery via ligand attachment.
- Reported high purity supports reproducible formulation.
- Soluble in water and DMSO with warming and sonication.
eMolecules 2698339-32-9 | Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane | Broadpharm447.448 | C20H25N5O7 | 95.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NC(COCCC(O)=O)COCCC(O)=O)cc1 | 50mg | 649280885
Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane | Broadpharm | 2698339-32-9447.448 | C20H25N5O7 | 95.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NC(COCCC(O)=O)COCCC(O)=O)cc1 | 50mg | 649280885
![eMolecules 1312309-63-9 | Azido-PEG2-acid | Broadpharm | MFCD20926378 | 203.198 | C7H13N3O4 | 98.000 | OC(=O)CCOCCOCCN=[N+]=[N-] | 1g | 112541481](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1687770.jpg-250.jpg)
eMolecules 1312309-63-9 | Azido-PEG2-acid | Broadpharm | MFCD20926378 | 203.198 | C7H13N3O4 | 98.000 | OC(=O)CCOCCOCCN=[N+]=[N-] | 1g | 112541481
Azido-PEG2-acid | Broadpharm | 1312309-63-9 | MFCD20926378 | 203.198 | C7H13N3O4 | 98.000 | OC(=O)CCOCCOCCN=[N+]=[N-] | 1g | 112541481
Creative Pegworks 4-Arm PEG-Amine, MW 20k, 1 g
4-Arm PEG-Amine is a multiarm PEG derivative with amine groups at each terminal of the four arms connected to one pentaerythritol core. The reactive primary amine or NH2 group can rapidly react with activated carboxyl acid such as NHS ester to form stable amide bonds.
Medchemexpress LLC Dbco-peg2-acid | 2304558-25-4 | ≥95.0% | C26H28N2O6 | 100 MG
DBCO-PEG2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain Azide groups. PROTACs themselves are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker.
- Utilized in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- PROTACs degrade target proteins via the ubiquitin-proteasome system.